Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder
Identifieur interne : 001520 ( Main/Exploration ); précédent : 001519; suivant : 001521Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder
Auteurs : Thien Thanh Dang-Vu [Canada, Belgique] ; Jean-François Gagnon [Canada] ; Mélanie Vendette [Canada] ; Jean-Paul Soucy [Canada] ; Ronald B. Postuma [Canada] ; Jacques Montplaisir [Canada]Source :
- Neurology [ 0028-3878 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objectives: Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with 99mTc-ethylene cysteinate dimer (ECD). Methods: Twenty patients with IRBD were scanned at baseline during wakefulness using 99mTc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution. Regression analysis between rCBF and clinical markers of neurodegeneration (motor, color vision, olfaction) looked for neural structures involved in this process. Results: Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients. Conclusions: 99mTc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD is predicted by abnormal perfusion in the hippocampus at baseline. Perfusion within this structure is correlated with clinical markers of neurodegeneration, further suggesting its involvement in the development of presumed synucleinopathies.
Affiliations:
- Belgique, Canada
- Province de Liège, Québec, Région wallonne
- Liège, Montréal
- Université de Liège, Université du Québec à Montréal
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Montreal</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Exercise Science and Center for Studies in Behavioral Neurobiology, Concordia University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Cyclotron Research Centre, University of Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Centre Hospitalier Universitaire de Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Department of Neurology, Centre Hospitalier Universitaire de Liege</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montreal</s1><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Montreal General Hospita</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Neurology, Montreal General Hospita</wicri:noRegion></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Psychiatry, University of Montreal</s1><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Psychiatry, University of Montreal</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Hippocampus</term><term>Nervous system diseases</term><term>Rapid eye movement sleep</term><term>Sleep disorder</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term><term>Pathologie du système nerveux</term><term>Hippocampe</term><term>Sommeil paradoxal</term><term>Comportement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with <sup>99m</sup>Tc-ethylene cysteinate dimer (ECD). Methods: Twenty patients with IRBD were scanned at baseline during wakefulness using <sup>99m</sup>Tc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution. Regression analysis between rCBF and clinical markers of neurodegeneration (motor, color vision, olfaction) looked for neural structures involved in this process. Results: Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients. Conclusions: <sup>99m</sup>Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD is predicted by abnormal perfusion in the hippocampus at baseline. Perfusion within this structure is correlated with clinical markers of neurodegeneration, further suggesting its involvement in the development of presumed synucleinopathies.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li></country><region><li>Province de Liège</li><li>Québec</li><li>Région wallonne</li></region><settlement><li>Liège</li><li>Montréal</li></settlement><orgName><li>Université de Liège</li><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></noRegion><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></region><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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